Last updated: October 19, 2020

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Welcome to our guide on all things vitamin B12. Did you now that this nutrient is essential to the proper functioning of many processes in our bodies? Including allowing red blood cells and neurons to work under optimum conditions. Unfortunately, as we age we begin to lose the ability to properly absorb this key vitamin.

Did you know that vegans and those following restrictive diets could also be at risk of entering a vitamin B12 deficiency? In the sections ahead we have put together a comprehensive summary of all the things you should know about vitamin B12. We have included detailed information about its benefits, characteristics, varieties and many more relevant facts about this important nutrient.

Key Facts

  • Vitamin B12 supplements are meant for those looking to replenish their vitamin B12 levels or those who don’t get enough of this vitamin through their diet.
  • There are many presentations of this supplement, you can find it in: pills, capsules, drops, and injections. You will have no trouble finding tablets and capsules at any Walgreens or supermarket.
  • If you have no trouble swallowing pills, tablets and capsules will work well. Drops and injections are meant to treat more severe deficiencies in a more immediate manner.

Ranking: Best vitamin B12 supplements on the U.S. market

In this section, we have included the absolute best vitamin B12 supplements available in North America. We hope this selection will help you better understand the possibilities within this market. Moreover, we have included a brief description of each product to help you compare them. We have also made sure to include products apt for vegans!

No. 1: Nature Made – Vitamin B12

Nature Made’s B12 supplement provides 150 soft gels of this essential vitamin. This supplement provides the daily intake of vitamin B12 you need to support the functions of your body. It helps to support nervous system functioning and assists the body in converting food into cellular energy. Each capsule contains 1000 mcg of B12. This B12 supplement has been shown to help those with underactive thyroids, hair loss, increased energy and strength, increased metabolism and more.

This product is USP-verified, setting the official standard to ensure quality dietary supplements. There are no synthetic dyes, colouring, no artificial flavours, is derived from natural sources and is 100% gluten-free. The other ingredients included within the product are soybean oil, glycerin, yellow beeswax, water and rapeseed lecithin. Adults should take 1 soft gel daily with water and a meal. Consumers love how small and easy to take this capsule is.

No. 2: aSquared Nutrition

This high potency, high supply supplement is the best value B12 supplement offered on Amazon. The supplement contains 5000 mcg per tablet with a total of 120 tablets for a full 120 days supple. This vitamin B12 formula supports your metabolism by helping it covert fats, carbs and proteins into energy more efficiently. More than just a memory enhancer, aSquared Nutrition’s supplement helps improve energy and supports a strong nervous system.

These B12 tablets help improve brain function, maintain healthy brain cells and reduce overall fatigue. They can also help relieve an upset stomach and constipation, giving your digestive system some much-needed relief. There are tremendous benefits to cardiovascular heart health as well as clearer, healthier-looking skin. These B12 vitamins come in a tablet pill format, only using premium vitamin B12, ensuring that their supplements have passed extensive quality control testing before being blotted and sold.

No. 3: Amazon Elements – Vitamin B12

Amazon’s Top Choice for B12 supplements, this B12 vitamin comes in the form of a delicious berry flavoured lozenge. It’s made with all-natural berry flavours and flavours from other natural resources as well. This delicious and more than pleasant vitamin supplement can help you with a multitude of processes in the body; aiding in digestion, nervous system health, boosting the metabolism, providing more energy and more.

This product is just as effective as vitamin B12 shots and other injection treatments at a price that everyone can afford. There are no artificial colours, flavours or chemical preservatives. It is completely vegan and gluten-free and will provide you with at least a 2 month supply of vitamin B12 if taken daily. The manufacturers suggest keeping this supplement in a cool and dry place. The label comes with a convenient and modern technology barcode that you can scan using the Amazon app to learn about the purity and quality of this supplement.

No. 4: Solimo – Vitamin B12

The amazon brand Solimo is another one of Amazon’s top-rated products due to its high quality and delicious, easy to take form. These supplements provide 3000 mcg in each raspberry flavoured gummy. The raspberry flavour of these gummies make you feel like you’re eating a tiny little treat, however not as unnaturally sweet as other conventional gummy vitamin supplements. It’s flavoured with natural flavours and us gluten-free, free of wheat, dairy, soy and egg.

These supplements are soft and pectin-based as well as vegan-friendly. Each serving consists of 2 gummies, containing only 3 grams of carbohydrates. It contains citric acid for maximum absorption and has been shown to help increase metabolism, digestive system health, immune system health, help increase and restore the body’s natural energy stores and enhance the body’s overall function. These supplements are a great option for those who hate taking pills or getting shots but require extra B12 supplementation.

No. 5: Natrol – Vitamin B12

Vitamin B12 is an essential element for the production of healthy nerve and blood cells, allowing the body to properly help remove carbon dioxide and other toxins from your body. This supplement gives you the proper doses of this necessary vitamin to support the healthy functioning of your cardiovascular system and nervous system. It promotes energy via Natrol’s active and high potency B12 that easily moves throughout the body’s energy pathways to support energy production.

The fast-dissolving 5000 mcg tablets are quickly and efficiently absorbed by the digestive system to contribute to the health of our blood cells. Each bottle comes with 200 tablets that are all naturally sweetened, flavoured and vegetarian-friendly. They have a great taste and are easy to take even without water, anytime and anywhere. The delicious strawberry flavour will make you forget you’re taking in compact nutrients and not a tasty treat.

Shopping Guide: Everything you should know about vitamin B12

Did you know that one of the key responsibilities of vitamin B12 is enabling the transport of fragmented carbon atoms – specifically methyl and hydroxyl? This means that B12 is also involved in the exchange of hydrogen atoms, a process essential to human health!

Vitamin B12 is essential to the proper functioning of the body.
(Source: Hootie2710: 61493150/

Want to know more? In this next section, we cover all the must-know facts of vitamin B12.

How does vitamin B12 work in our body?

Vitamin B12 is actually involved in a number of important reaction in the body. For example, it has a role in blood creation, cell division and it is also has a key role in nervous system regulation. Moreover, it also participates in DNA synthesis, fat metabolism, hormone regulation and enabling neurotransmitters to work optimally.

Nonetheless, probably the most important role of vitamin B12 in our bodies is caring for the immune system. For this reason, it is crucial to keep adequate levels of this vitamin in our reserves. Having proper levels of this vitamin in our bodies can help you fight many different symptoms and diseases. Let’s look at a few of them:

  • Anemia
  • Chronic fatigue
  • Diseases of the nervous system
  • Mental illness such as depression, dementia and schizophrenia
  • Autoimmune diseases

Which foods contain high levels of vitamin B12?

Because vitamin B12 can only be synthesized by microorganisms, the best way to absorb the vitamin B12 in them is to eat their meat. Moreover, vitamin B12 can also be found in legumes if you’re looking for a vegetable source.

Nonetheless, we should mention that vegetable sources of vitamin B12 actually contain a lot fewer vitamin B12 than meat sources. This means that, if you’re vegan or you follow a very restrictive diet, supplementation of this essential vitamin is strongly recommended.

Should I be supplementing vitamin B12 if I’m vegan or vegetarian?

Because vitamin B12 is mainly found in animal products, especially meat and dairy products, those following one of these diets, should pay special attention to their B12 levels. Luckily, in North America, we have access to fortified foods, which can be good sources of this vitamin too. Nonetheless, if ingesting this essential vitamin through your diet is not an option, supplements are always a good option.

Moreover, vegetarians, despite being able to consume dairy products, should also keep an eye on their B12 levels. At the end of the day, if you’re unsure about your health status, you should consult a doctor and get a blood test to check that all the nutrient levels are in order.

Did you know that one cup (240 ml) of soy milk contains 2.6 mcg of vitamin B12 or 45% of the RDI.

Even if I meat, can I still enter a vitamin B12 deficiency?

A vitamin B12 deficiency is most often caused by digestive system difficulties, which can occur if the body is unable to absorb B12 from foods and liquids. We should also mention that those with very poor eating habits may also suffer from one of these deficiencies.

Vitamin B12 is essential for vegans or vegetarians.
(Source: Anschiz: 74119582/

We would suggest that any of the at-risk groups we have mentioned stay vigilant concerning their nutrient levels.

What are the symptoms of vitamin B12 deficiency?

As it stands, vitamin B12 deficiencies are very common in the United States. This is mainly due to diet choices and gastrointestinal conditions. Moreover, another demographic at risk is elderly, since their organisms are no longer able to properly absorb this nutrient.

Unfortunately, symptoms of a vitamin B12 deficiency can take years to show up, and diagnosing it can be complex. Because low levels of B12 cause your folate levels to drop. A B12 deficiency can sometimes be mistaken for a folate deficiency.

Stay vigilant and keep an eye out for some of these symptoms of B12 deficiency:

  • Pale or yellow skin
  • Dizziness
  • Vision problems
  • Mood swings
  • Mouth sores
  • Tiredness and fatigue

What are the potential repercussions of a sustained vitamin B12 deficiency?

The long-term impact of a sustained vitamin B12 deficiency is closely related to the symptoms. For instance, those suffering from a deficit of B12 will feel tiredness and dizziness. This happens because their bodies are unable to produce enough red blood cells, which in turn fails to provide the body with enough oxygen.

The functioning of the nervous system will also be affected by a vitamin B12 deficiency. This is because B12 plays an important role in the production of myelin, which insulates your nerves and is critical to your nervous system function. Symptoms that the nervous system has been compromised can be the feeling of pins and needles and changes in mobility.

How does a vitamin B12 deficiency come about?

Unfortunately, vitamin B12 deficiencies are often years in the making and only manifest symptoms when the condition has become critical. Because vitamin B12 is stored in the liver, we usually have a 2 to 3 years reserve, which means that if we’re not getting enough vitamin B12 for years, we wouldn’t see symptoms until our reserves had completely run out.

In North America, you can find many different methods of intake for B12 supplements.
(Source: Badmanproduction: 14501320/

These are the top three causes of depleted vitamin B12 levels:

  • Low vitamin and nutrient intake
  • Issues absorbing vitamins
  • Increased need for vitamin B12 (ie: aging, pregnancy)

Vegetarians, pregnant or breastfeeding women, the elderly and others at high risk of deficiency may want to track their diets closely to make sure they’re getting enough B12.

Luckily for those on vegans diets, fortified foods can be good sources of this vitamin. Nonetheless, it may still be difficult to reach the RDI and they should still keep a close eye on their blood nutrient levels.

Some population groups actually require higher levels of this vitamin on a daily basis. Pregnant or breastfeeding women and those suffering from autoimmune diseases are often prescribed high doses of this vitamin.

Helen WestRegistered Dietician
“Appropriate vitamin B12 levels are key to a healthy pregnancy. They’re important for the prevention of brain and spinal cord birth defects.”

Our body’s ability to properly absorb vitamin B12 may be disrupted as a result of certain conditions. Most of the time, B12 deficits can be attributed to one of these conditions:

  • Gastrointestinal diseases, such as gastritis or Crohn’s disease
  • Complications in the liver
  • Alcoholism
  • Chain smoking
  • Consumption of birth control pills

What is the recommended daily intake of vitamin B12?

The RDI of vitamin B12 will be specific to each individual, things like pre-existing health conditions and diet may play a role in your specific RDI. Check out the table below to get an overview of general dosing:

Population group Dosage
Healthy people Low, 3-50 μg
Vegans and vegetarians Medium, 100-250 μg
Pregnant women High, 251-500 μg
People with severe stomach problems Very high, 501-3,000 μg
People with severe vitamin B12 deficiencies Megadoses, over 3000 μg

How much do vitamin B12 supplements usually cost?

Like with most supplements, the price of the products will vary according to formula, quality of ingredients and brand. However, keep in mind that contrary to what one may think: the higher de B12 content, the cheaper the price.

The next table contains the general prices for B12 supplements in the United States:

Type Price
Sublingual tablets (30 tablets) aprox. 7-30 USD$
Softgels (30 tablets) aprox. 20-30 USD$
Spray or drops (100 ml) aprox. 27-40 USD$
Injections (100 ml) aprox. 10-60 USD$

Overall, sublingual or chewable tablets are the most affordable presentations of this vitamin. In contrast, B12 injections are the most costly. Injections are often doctor prescribed and fundamental to pregnant women and those with extreme B12 deficiencies.

What types of vitamin B12 supplements are there and which one is right for me?

In the United States right now, there are essentially seven presentations of this vitamin available:

  • Tablets or capsules
  • Sublingual tablets
  • Softgels
  • Spray and
  • Drops
  • Injections and
  • Ampoules

Keep in mind the different products you’ll find, they will have different concentrations, formulas, advantages and disadvantages. In order to find the right product, we strongly suggest that you carefully evaluate your needs and lifestyle. To help you understand the different formats better, we present you each one with their advantages and disadvantages in the table below:

Sublingual tablets Capsules Spray and drops Injections and ampoules
Low Moderate Moderate Low or high
Easy to ingest Can be difficult to swallow Very easy to ingest Difficult to take
Contains flavors and other materials. Pure, contains few added ingredients. Contains certain added ingredients. Certain ampoules or injections contain cyanocobalamin, a synthetic B12 compound.
Long-term effects, since the daily dose is low. Long-term effects, since the daily dose is low. Long-term effects, the vitamin begins its effect at the time of intake. The dose is very high, therefore its effects are immediate.

Vitamin B12 is needed for the production of serotonin, a chemical responsible for regulating mood. Vitamin B12 supplements may help improve mood in people with an existing deficiency.

Purchase Criteria

When looking to buy any kind of supplement, it is important to make a well-informed decision. Throughout this article, we have given you all the knowledge you need to understand your personal relationship with vitamin B12. In this last section, we want to present you with a final set of criteria that will help you effectively evaluate products in order to make the best purchase.

  • Effectiveness
  • Side Effects
  • Price
  • Allergens
  • Active Ingredient
  • Aroma


The reason why you need to supplement with B12 will determine how effective you need your supplement to be. For instance, if you suffer from a serious deficiency, ampoules are great options. Moreover, if your case is severe, a doctor may prescribe injections. These are reserved for the most serious symptoms of B12 deficiencies. In contrast, if you’re just looking to supplement your diet, the normal over the counter supplements will do just fine.

Side Effects

People with allergies, dietary restrictions and sensitivities should exercise caution when buying vitamin B12 supplements. Some products may have irritants and additives like magnesium stearate, which can interact negatively with some people, resulting in heartburn and headaches.

The best food sources of vitamin B12 are animal meat.
(Source: Gresei: 36177030/

Always properly research the product and it’s ingredients before making your final purchase.


The price of the product you choose should come into play after you have evaluated its quality and ingredients. A good indicator of quality is that the manufacturer offers a money-back guarantee if not fully satisfied with the product. When it comes to supplements, more often than not, price is closely related to quality.


In North America today the most common allergens are eggs, milk, soy, gluten, peanuts, and other nuts. If you are allergic to any of these substances, we would advise looking for vegan options, these are often fully allergen-free.

In some rare cases, some people may be allergic to the active form of the vitamin: cyanocobalamin – cobalamin for short. Keep in mind that this active form is often present in heavier dose products like ampoules and injections.

Active Ingredient

In the United States, there are varying forms of the vitamin available. The most popular version of the vitamin in North America are:

  • Cyanocobalamin:This form is formed by combining vitamin B12 and cyanide. Even though it is simple to synthesize, it can cause severe allergic reactions and serious complications to some. For this reason, we would advise for smokers and people with kidney problems to stay away from this substance.
  • Hydroxocobalamin:This form has the benefit that it doesn’t release toxic substances into our body. It is often part of cobalamin injections and it’s presented in high doses for detoxification purposes.
  • Methylcobalamin:This is a bioactive form of vitamin B12. This means that it comes ready to be directly processed by the body. The biological structure of this substance is identical to vitamin B12, making it possible for the liver to store it without complications.
  • Adenosylcobalamin:Just like methylcobalamin, this substance is an active form of vitamin B12. Therefore, adenosylcobalamin can also be stored in the liver as part of the cobalamin reserve.


Considering supplements with aromas can be very useful in some cases. Children in particular are especially sensitive to smells. There are different types of aromatic components that may be used in some supplements, check out the most common in North America:

  • Natural aromatic extracts:These come from natural sources such as clove oil, rose water, and vanilla.
  • Natural-identical aroma extracts:These extracts are generated synthetically so that they are biologically the same as the natural versions. An example is synthetic vanilla.
  • Artificial flavor extracts:These are generated synthetically.

We would always advise taking the more natural path, especially with supplements for children.


By now you probably know the importance of vitamin B12 in essential functions of our bodies. This essential nutrient plays a key role in our sustained and long term health. If you’re looking to supplement this essential nutrient, keep in mind there are several types of this vitamin and you should choose the format that best suits your needs.

There are certain population groups that are at higher risk of suffering a deficiency of this important vitamin. Vegetarians, pregnant or breastfeeding women and the elderly for example, are at high risk of deficiency may want to track their diets closely to make sure they’re getting enough. Always make sure you do your research before purchasing a product!

If you found the information in this guide useful, don’t hesitate to share it with your loved ones, or leave us a comment with your thoughts in the comments section below!

(Featured image source: Srihon: 58137272/

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